AEK is in store for an ominous weekend as they attempt to down Olympiacos at home, with the Piraeus giants looking for vengeance after being knocked out of the Cup by the same opposition.

The reigning premiers host Enosi at “Georgios Karaiskakis” Stadium on Monday morning (AEST) for what looms to be a stellar fifth round of the Greek Super League play-offs filled with challenging contests.

Olympiacos has lots riding on this weekend, with a win not only avenging their Cup elimination at the hands of AEK but also keeping them just in range of the championship.

The Double-headed eagle of the South will be just as motivated to win as they strive to ascend into outright first.

Panathinaikos, who is currently level with AEK, has a daunting trip of their own planned as they take on PAOK at “Toumba” stadium.

The Greens are hoping for lightning to strike twice as they attempt to beat the Thessaloniki outfit in their own backyard for the second time this season.

The “Trifylli” will be at risk of relinquishing their place in first, should they fail to earn maximum points, adding further stakes to an already herculean-sized task.

PAOK, meanwhile, will do everything they can to spoil Panathinaikos’ title charge and keep themselves within reach of Olympiacos (currently third).

Volos hosts Aris in yet another major clash as both sides strive for fifth place, the final European qualifying spot.

The two teams are separated by a single point, making this a huge opportunity for either team to secure an important advantage over the other.

Aris, in particular, has much to gain as a win against the Magnesia club would give them a four-point lead which could very well be enough to guarantee fifth, given the quality of the other four teams in the play-offs.

Levadiakos goes up against Ionikos at home on Sunday morning (AEST) in the fourth round of the play-outs for what is a huge match in the context of the relegation scrap.

A victory would strongly boost the Nikaia outfit’s odds of avoiding a straight drop into the second division, but a loss could also mean they take the “blue-greens'” place in last.

Lamia has a tough encounter with Atromitos lined up at “Athanasios Diakos” ground, with the Fthiotida team hoping to somehow down the currently top-ranked side in the relegation group and climb out of second-last.

Giannina faces Panetolikos at home in a must-win match as they try to guarantee their safety as a top-flight club, sitting only two points adrift of bottom place.

OFI collides with Asteras Tripolis as the Cretans aim for their third straight success in a bid to leap ahead of Atromitos on the ladder.

Play-offs Rd 5 fixtures (AEST)

Volos-Aris: 00.30, Mon 24 Apr

PAOK-Panathinaikos: 03.00, Mon 24 Apr

Olympiacos-AEK: 04.00, Mon 24 Apr

Play-outs Rd 4 fixtures (AEST)

Giannina-Panetolikos: 02.15, Sun 23 Apr

Lamia-Atromitos: 02.15, Sun 23 Apr

Levadiakos-Ionikos: 02.15, Sun 23 Apr

OFI-Asteras Tripolis: 02.15, Sun 23 Apr