The two Athenian giants go head-to-head in a major clash that could set the tone for their respective league campaigns.

Panathinaikos hosts AEK at “Leoforos” Stadium on Tuesday morning (AEST) in the Greek Super League’s fifth round, with the two best teams from last season hoping to showcase their quality and credentials as title threats once again.

The two sides are both coming off amazing wins in Europe midweek, though that represented the start of an agonizing two-week period that will see them each play five fixtures.

The Greens will particularly feel the pressure to perform, being the home team and also the side thirsting for revenge after losing the league to Enosi last season.

For AEK, this represents a key opportunity to truly stamp their authority in the championship after a rather tame start to their campaign by their standards (one win and two draws).

A victory here would do wonders for both clubs, given their tough schedules, thus increasing the importance of getting all three points in this derby for either club.

Olympiacos goes up against Kifisia at “Georgios Karaiskakis” ground on Monday morning as they hope to make light work of their newly promoted opponents.

The Piraeus outfit will be in desperate search of maximum points, especially after losing their Europa League contest with SC Freiburg midweek.

PAOK, the other Greek team that had European football midweek, travels away to challenge Giannina with the goal of earning nothing less than three points.

Aris is preparing for a visit from a struggling Panetolikos side, with the Thessaloniki club striving for a triumph that boosts their league position and simultaneously extends their opposition’s winless run.

Volos looks to end their own winless streak when they face Asteras Tripolis at home after a tough start to their season, having played AEK and Panathinaikos in two of their opening four games.

Atromitos travels away to meet with a high-flying OFI team that is currently sitting in third, the Peristeriotes hoping to pull off a mighty upset and get their first victory on the board.

Panserraikos competes with Lamia at home in what looms as an interesting battle that potentially has implications on the relegation race.

The Serres-based side have performed relatively well so far, having recorded three straight draws that includes a 1-1 result with AEK, though the true test for them will be whether they can take it to the next step and bag a victory.

Lamia have also shown plenty of positive signs in the opening four rounds, though they have flirted with relegation in the past two seasons.

This clash thus represents a crucial chance for them to prove they can keep well away from the bottom places this term and ensure their spot in the top division for another year.

Greek Super League Rd 5 fixtures (AEST)

OFI-Atromitos: 00.30, Sun 24 Sep

Panserraikos-Lamia: 03.00, Sun 24 Sep

Olympiacos-Kifisia: 00.00, Mon 25 Sep

Aris-Panetolikos: 00.30, Mon 25 Sep

Volos-Asteras Tripolis: 03.00, Mon 25 Sep

Giannina-PAOK: 03.30, Mon 25 Sep

Panathinaikos-AEK: 04.00, Tue 26 Sep